13 Comments
Dec 31, 2021Liked by John Skylar, PhD

I encountered yesterday someone who said omicron is “just a cold” and “people aren’t dying from it.” When I brought up hospitalization rates and death of vacc vs unvacc ppl I got the line about complications and other underlying health problems that caused the death meaning that the deaths were misrepresented as caused by COVID. This is that old argument of course, and in conversation I didn’t have the numbers at my mental fingertips. Very frustrating. And then there is another discussion I have been having with a family member about getting their 3 children ages 8, 6 and 6 to be vaccinated. The fact that they are on the “low end” of acceptable ages has been that argument. I tried to say that the issue with the under 5 group was vaccine response not side effects but that didn’t help the discussion. Thank you for your insights. I often use your arguments when dealing with the nay sayers in my sphere. Sigh.

Expand full comment

It may seem like a small detail: the antigenic target isn't the spike, it's the regional binding domain (that is unique). Will it have the same efficacy as spike-based vaccines when used at commercial scale?

Expand full comment
Dec 31, 2021·edited Dec 31, 2021

Biological E is not *that* small. Their reported revenue was around $125 million as of 2019, presumably substantially higher post-pandemic since they're mostly a vaccine maker. They now produce four approved COVID-19 vaccines: Novavax's entry, Janssen's, A-Zs, and Corbevax. Their total production is in the billions of doses(!).

Smaller than the giants, surely.

Forbes India reports they're also working on both an mRNA vaccine and a viral vector vaccine: https://www.forbesindia.com/article/innovation/hyderabads-biological-e-the-dark-horse-in-indias-vaccine-race/64733/1

EDIT: does NYC break out numbers for those who have already had COVID-19, but not been vaccinated? I'd love to compare the protection from symptomatic disease vs. vaccination vs. both (for folks like yourself and your bride).

Expand full comment